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KMID : 0438520080150010038
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Journal of the Korean Society of Neonatology
2008 Volume.15 No. 1 p.38 ~ p.43
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Correlation of Cord Serum Adiponectin and IGF-I with Fetal Growth in Healthy Term Neonates
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Kim Ji-Young
Cho Su-Jin
Kim Hae-Soon
Park Hye-Sook
Park Eun-Ae
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Abstract
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Purpose: The purpose of this study was to evaluate the relationship between cord serum adiponectin (APN) and IGF-I concentrations and fetal growth.
Method: Umbilical cord serum APN and IGF-I concentrations were measured in healthy term singleton deliveries (n=72). The association of cord serum APN and IGF-I concentrations was evaluated in relation to birth weight, height, head circumference, gender, ponderal index, placental weight, feto-placental (F/P) weight ratio, maternal weight gain, and maternal body mass index (BMI).
Result: The mean cord serum APN was 29.2+/-10.46 microgram/mL. The cord serum APN and birth weight demonstrated a bell-shape relationship. The cord serum APN concentration was higher in females than males (P=0.001). The cord serum APN was negatively correlated with maternal BMI (r=-0.301, P=0.027), but the mean cord serum APN concentration was not correlated with birth height, birth head circumference, ponderal index, placental weight, F/P ratio, or maternal weight gain. The mean cord serum concentrations of IGF-I was 51.26+/-21.54 ng/mL. The cord serum IGF-I concentration was positively correlated with birth weight (r=0.312, P=0.009), but not birth height, ponderal index, placental weight, F/P weight ratio, or maternal BMI.
Conclusions: APN demonstrated a bell-shaped relationship with birth weight in healthy term infants. IGF-I was highly correlated with fetal growth, especially birth weight.
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KEYWORD
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Adiponectin, Insulin like growth factor-I, Fatal growth
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